Advances in Tooth Agenesis and Tooth Regeneration

Introduction

Research in the field of tooth agenesis and regeneration has made significant progress in recent years, aiming to address the challenges posed by congenital and acquired tooth loss. Innovative strategies, such as inactivating USAG-1 and utilizing anti-USAG-1 antibodies, have shown promise in treating tooth anomalies. The prevalence of congenital tooth agenesis and partial tooth loss underscores the importance of early diagnosis for improved patient outcomes and quality of life.

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Classification of Tooth Agenesis

Tooth agenesis can be categorized based on the number of missing teeth and can be further classified as syndromic or non-syndromic forms. Syndromic tooth agenesis is associated with systemic conditions, while non-syndromic cases primarily involve congenitally missing teeth. Understanding the genetic factors contributing to tooth agenesis is crucial, with genes like MSX1 and PAX9 playing significant roles in tooth development and anomalies.

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Third Dentition

In addition to the deciduous and permanent dentition, humans may also develop a "third dentition" characterized by extra teeth. Studies have shown the presence of rudimentary third dentition in mammals, with implications for tooth regeneration. Understanding the role of the third dentition in tooth formation and regeneration is essential for advancing regenerative therapies.

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K. Bessho, C.L. Huang, H. Kiso, A. Murashima-Suginami, V. Ravi, M. Sugai, Y. Tabata, J. Takagi, K. Takahashi and Y. Tokita -- Advances in tooth agenesis and tooth regeneration - Flipbook by Fleepit