Mild cognitive impairment: To diagnose or not to diagnose

Introduction

Mild cognitive impairment (MCI) is a condition that falls between normal aging and diagnosed dementia, characterized by a slight decline in cognitive function. Diagnosing MCI is a controversial topic as some argue it may lead to unnecessary treatment or anxiety, while others see it as a clinical syndrome that warrants early intervention. The lack of consistent diagnostic criteria makes it challenging to diagnose MCI in a reliable manner in clinical settings.

(Source: Page 1)

Epidemiology

MCI is strongly linked to age, with a higher risk of developing dementia in individuals with MCI compared to those with normal cognitive function. Studies show variations in the progression of MCI to dementia, with different risks associated with amnestic and non-amnestic MCI subtypes. Identifying individuals at risk of dementia remains a debated topic among clinicians.

(Source: Page 2)

Causality Hypothesis/Pathophysiology

The underlying causes of cognitive decline in MCI are still under debate, with theories focusing on factors such as amyloid-beta accumulation and other reversible conditions like nutritional deficiencies or depression. Recent findings on limbic-predominant age-related TDP-43 encephalopathy (LATE) have added to the uncertainties surrounding the pathology of cognitive decline in aging.

(Source: Page 3)

Etherton-Beer Christopher, Page Amy and Wang Kate - Mild cognitive impairment: To diagnose or not to diagnose - Flipbook by Fleepit