Summary of Technology Journal iPSCs and Microphysiological Systems (MPS)

Electrophysiological analysis of atrial and ventricular axoCells cardiomyocytes utilizing 3Brain’s CorePlate enabled HD-MEA

The study evaluates the electrophysiological properties of iPSC-derived atrial and ventricular cardiomyocytes using high-density microelectrode array technology. Atrial cells showed a higher beating rate than ventricular cells, and both cell types responded predictably to isoproterenol. The combination of CorePlate technology and iPSC-derived cardiomyocytes proved effective for cardiac modeling and drug screening.

Beating heart-on-chip to model atrial and ventricular cardiac chambers

The development of atrial and ventricular beating heart-on-chip models using hiPSC-derived cardiomyocytes within the uBeat® Platform showed chamber-specific gene expression, synchronous contraction, and distinct electrophysiological profiles. The models were effective in evaluating the cardiotoxic effect of compounds, offering a reliable platform for disease modeling and personalized medicine.

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